Dysregulation of the Cortisol Awakening Response (CAR) and Mental Wellbeing
In particular, having a dysregulated CAR - meaning it is either too high or too low - can lead to symptoms of depression, anxiety, affective disorders, chronic fatigue and increase risk of autoimmunity. This is because CAR has a unique ability to regular inflammation, blood sugar, as well as memory and recall due to the fact that the hippocampus is so tied in with CAR. It also plays a role in infection regulation and so can have far-reaching effects on the body’s resilience to viruses and bacteria.